ABSTRACT
Objective To investigate changes in serum levels of Th22 cell ? related cytokines and complements in patients with drug eruption before and after treatment, and to explore their possible roles in the occurrence and development of drug eruption. Methods This study included 35 patients with drug eruption, and 35 sex?and age?matched healthy controls. Five milliliters of peripheral blood samples were collected from the controls and patients before and after treatment. Enzyme?linked immunosorbent assay(ELISA)was performed to measure serum levels of interleukin 22(IL?22)and IL?13, and the cytometric bead array(CBA)system was used to determine serum levels of tumor necrosis factor?α(TNF?α) and complement components C3a, C4a and C5a. Results Before treatment, the patients with drug eruption showed significantly higher serum levels of IL?22(40.85 ± 14.56 vs. 29.09 ± 8.66 ng/L, t=5.549, P 0.05). Correlation analysis showed positive correlations between complement C3a and C4a serum levels(r = 0.660, P < 0.05), between C3a and C5a serum levels(r = 0.404, P < 0.05), between C4a and C5a serum levels(r = 0.501, P < 0.05), and between IL ? 22 and TNF ? α serum levels(r = 0.573, P = 0.005), but negative correlations between IL ? 22 and complement C3a serum levels(r = -0.490, P = 0.005), in patients before treatment. Conclusion The activation of Th22 cell?related cytokines and complements may play important roles in the occurrence and development of drug eruption, and IL?22 may participate in the regulation of complements.
ABSTRACT
Objective To evaluate the relationship between body mass index (BMI) and blood pressure,blood glucose,lipid profiles and blood uric acid in healthy populations in Hefei of Anhui province.Methods A total of 3 640 healthy adults were enrolled to analyze the relationship between BMI and blood pressure and serum levels of lipid profiles,uric acid and glucose.Results The mean BMI of the subjects was (25.5±2.8) kg/m2 (men vs women:(26.3±2.5) vs (23.9±2.8) kg/m2).BMI showed a significant difference in different age groups (P＜0.05).Different BMI subgroup had statistically significant difference in blood pressure,glucose,lipid profiles and uric acid.In different gender and age groups,BMI,blood pressure,glucose,blood lipid and uric acid were found to be significantly different.Conclusion The prevalence of obesity and overweight is high in our health check-up populations.It should be important to prevent and control hypertension,high blood glucose,high blood uric acid and other chronic diseases.
ABSTRACT
Objective To explore how to perform effective health management for the metabolic syndrome(MS) in the health examination center. Methods A total of 153 subjects diagnosed with MS and the same number of healthy controls were analyzed. All patients received health management for 12 months and an impact evaluation was conducted. Results Waist circumference, IBM, SBP, DBP, blood lipids of MS group were remarkably higher than those in normal control group, and there was statistical significance (P